Medical drama GREY’S ANATOMY (Peter Horton, US 2005–) features weddings as pivotal life events and has portrayed 14 unions over the program’s 13 seasons on ABC.This article is a synthetic approach combining communication, gender studies, and grounded theory methodology to examine weddings in GREY’S ANATOMY through a feminist lens. We employ Judith Butler’s theory of gender performance and Rich’s concept of compulsory heterosexuality to examine weddings throughout the show’s extensive run. Depictions of women and weddings demonstrate dissonance between hegemonic gender performance and the potential to redefine the performance of woman in one’s own ways. Tension exists between the program’s portrayal of traditional heterosexual weddings and its progressive inclusion of a lesbian ceremony. We argue that the program’s portrayal of both traditional white weddings and ceremonies which are more private and self-defined reflect the challenges inherent in navigating cultural expectations and personal objectives associated with performing as a woman in contemporary culture.